Thursday, March 12, 2015

New Research on Allergies and Dry Eyes- in Children

Image result for photos of children with allergies

Allergies and Dry Eye Disease often concur.  Here is a research study that supports this finding.  Tear film instabilities result in evaporative dry eyes.  

Evaluation of the Tear Film Instability in Children with Allergic Diseases

CONTEXT: The presence of dry eye syndrome (DES) in ocular allergic diseases was evaluated in several studies. Despite this, little exists about the tear film instability in atopic children including patients with allergic rhinitis (AR), allergic conjunctivitis (AC) and asthma. This is a study which presents intriguing findings regarding the relationship of tear film instability with clinical aspects in atopic children.

OBJECTIVE: To determine the tear film instability in children with AR, AC and asthma.
MATERIALS AND METHODS: One hundred and thirty-five consecutive children with AR, AC and asthma as study group and 45 children without any systemic and ocular abnormality as control group were included in the study. Skin prick tests, measurement of tear film breakup time (TFBUT), serum immunoglobulin E and eosinophil counts were performed in all patients. Also four subgroups of patients were designated as AR group (Group I), AC group (Group II), asthma group (Group III) and control group (Group IV).

RESULTS: Socio-demographic characteristics were similar except for family atopy between the groups (p > 0.05). The mean TFBUT was significantly lower in the study group (15.5 ± 4.4 s) than the control group (18.4 ± 2.9 s; p 0.000). Also, there was no significant differences in the percentage of the patients who had TFBUT<10 s (p = 0.066). In logistic regression analysis, atopy was found to be the determinant of lower TFBUT (OR = 16.33, 95%; CI = 1.17 to 228.05, p= 0.03).

CONCLUSION: The presence of tear film instability was higher in children with AC, AR and asthma. This finding should be taken in consideration in atopic children.

Dogru M, Gunay M, Celik G, Aktas A. Cutan Ocul Toxicol. 2015 Feb 19:1-4. [Epub ahead of print]

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TheraLife Eye is effective in reducing inflammation and stimulates tear flow for chronic dry eye relief. Often people with chronic dry eyes also have Blepharitis. Treating chronic dry eyes reduces the inflammation, and also helps to reduce the recurrence of blepharitis. It is highly recommended that those who have Blepharitis stay on TheraLife Eye long term to increase the rate of success.

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Monday, March 9, 2015

New Study on Sjogren's/Meibomian Dysfunction/Dry Eyes.

Sjögren’s Syndrome (SS) affects approximately 3.1 million Americans and 430,000 Canadians in North America. Ninety percent of the Sjogrens population is female and the disease is characterized by infiltration of lymphocytes into exocrine glands, including sebaceous, sweat, salivary, and lacrimal glands.

Recent experiments have also reported that a common finding in patients with Sjogrens is androgen deficiency, which may lead to meibomian gland dysfunction (MGD).1,2,3 MGD is a common clinical condition and a major cause of lipid tear deficiency and evaporative dry eye.4 To date, very few studies have investigated the physical changes or secretions of the meibomian glands (MGs) in patients with Sjogrens.

This abstract5 focuses on a study that evaluated Meibomian loss (dropout) and lipid layer thickness in patients with and without Sjogrens. Eleven participants with Sjogrens (1M and 10F; mean age=56.0±9.1yrs) and 10 non dry eye (NDE) controls (3M and 7F; mean age=58.5±4.7yrs) were recruited. All participants completed the Ocular Surface Disease Index (OSDI) questionnaire to assess dryness symptoms. Parameters evaluated include:

1. Non-invasive tear break up time (NITBUT)
2. Lipid layer thickness (LLT) was assessed by appearance using the Tearscope Plus (Keeler).
3. Meibomian Gland Imaging - The upper and lower lids of all subjects were everted and the MGs imaged using the infra-red (IR) camera of the Keratograph 4 (Oculus). Meibomian gland percentage drop-out score (MGDS) was obtained by digital analysis using ImageJ, which was based on the complete or partial gland loss observed in both lids. Subjective analysis (0-6 score) was also performed.


The Sjogrens group recorded significantly higher Ocular Surface Disease Index scores, reduced Lipid Layer Thickness and lower Tear Breakup Time compared to controls. Percentage Meibomian Gland loss and subjective Meibomian Gland Drop Out Score  was also significantly higher for the Sjogrens group.

Higher MGDS and reduced LLT and NITBUT may partly contribute to the severe ocular surface changes often observed in patients with SS. Meibography is a quick and easy assessment of the degree of MG drop-out. Digital grading via ImageJ may be time-consuming in a clinical setting, however, subjective methods for analyzing the physical loss of MGs is a good option and could aid in a better understanding and management of the disease.

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TheraLife Autoimmune Formula is a natural way to provide relief for both chronic dry eye, dry mouth and Sjorgren’s Syndrome. It works by:

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To learn more: click here.
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Watch a video
Want to talk to a doctor: Call toll free 1-877-917-1989
International (650) 949-6080
Send inquiries to
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1. Sullivan, DA et al. Androgens and dry eye in Sjögren’s syndrome. Ann N Y Acad Sci. 1999;876:312-24.
2. Sullivan, DA et al. Androgen deficiency, Meibomian gland dysfunction, and evaporative dry eye. Ann N Y Acad Sci. 2002 Jun;966:211-22.
3. Sullivan, DA et al. Sex steroids, the meibomian gland and evaporative dry eye. Adv Exp Med Biol. 2002;506:389-99.
4. Craig JP, Tomlinson A. Importance of the lipid layer in human tear film stability and evaporation. Optom Vis Sci. 1997;74:8-13.
5. Menzies, KL et al. Infrared Imaging of Meibomian Glands and Evaluation of the Lipid Layer in Sjögren’s Syndrome Patients and Nondry Eye Controls. Invest Ophthalmol Vis Sci. 2015 Jan 8;56(2):836-41. doi: 10.1167/iovs.14-13864.
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