Autologous Serum Drops for Chronic Dry Eye Treatment

Autologous Serum  Drops for Chronic Dry Eye Treatment

Autologous serum has been used as an eye drop to treat severe chronic dry eye treatments for a long time.  We will be discuss some of the pros, cons and precautions with using autologous serum drops as dry eye treatment. 

Autologous serum is prepared from one’s own blood, which is more compatible with one’s own tear composition.  It also contain many of the proteins, growth factors that one needs to promote healthy cornea.  Many people with Sjogren's are on or have been on autologous serum drop to treat their severe dry eyes.  The preparation is often done in a compounding pharmacy and stored in bottles for application. 

Bacterial Contaminationof Autologous Serum Drops

Derived from biological fluid (blood) autologous serum naturally has a high protein content, potentially creating a media for flourishing bacteria.  While a preservative could be added, its toxic effects could be harmful. Factors related to patient compliance ( storage conditions, contamination of the bottle tip to eye lids, dirty surfaces etc.) can often lead to eye infections.  .

A 2013 study cultured bottles of autologous serum eye drops from 21 dry eye patients and found that close to 4% were positive for either bacterial or fungal growth even before the bottles were opened. ¹ For this reason, the use of specialty sterilizing containers has been studied. Lopez-Garcia and colleagues² compared bottles with adapted mechanical filters versus conventional containers. After 7 days of use, almost 30% of non-filtered, conventional containers were contaminated, whereas after 1 month of use, only about 2% of filtered containers were contaminated. Consider consulting with your compounding pharmacy about ways to improve sterilization in the bottles of autologous serum eye drops.
  

Plasma Rich  in PRGF v.s. Traditional Autologous Serums Drops

Another approach is potentially using a plasma rich in growth factors (PRGF), as opposed to traditional autologous serum.³ While traditional autologous serum contains growth factors, neuropeptides, and vitamins that are common in the tear film, it can also include proinflammatory cytokines and immunoglobulins. Plasma, however, with an enriched platelet concentration (and with red and white blood cells removed) can also provide all of these beneficial growth factors and neurotrophic peptides but without the proinflammatory molecules. Only a few preclinical and clinical studies have been performed to date, all with positive findings,

Use of autologous eye drops for people with severe dry eyes can be life changing  There is currently no standardized protocol for how it should be prepared, stored, dosed, or discarded. Education and compliance are a must for successful therapy. 

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1.        Thanathanee O, Phanphruk W, Anutarapongpan O, et al. Contamination risk of 100% autologous serum eye drops in management of ocular surface diseases.Cornea. 2012;32(8):1116-9. 2. Lopez-Garcia J, Garcia-Lozano I. Use of containers with sterilizing filter in autologous serum eyedrops. Ophthalmol. 2012;119(11):2225-30. 3. Anitua E, Muruzabal F, Tayebba A, et al. Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies. Acta Ophthalmol. 2015;93:e605-14. 

What you should eat to prevent eye diseases, Dry Eyes, AMD, Diabetic Retinopathy.

Eat Right to Prevent Eye Diseases- Dry Eyes, AMD, Diabetic Retinopathy

There are many publications about diet and AMD - (Age related Macular Degeneration) .

However, there is a general lack of knowledge on nutrition and diet to prevent eye diseases,in particular dry eyes, AMD and diabetic retinopathy.  

Here is a general outline for diet on weekly basis.  

·         Eat your leafy greens… a handful a day keeps AMD away!

·         Eat cold water fish four times a week. Choose sustainable fish that is low in contaminants, like wild Alaskan salmon, mackerel (not king mackerel), rainbow trout or sardines.

·         Eat orange peppers (they are high in zeaxanthin), two peppers per week, cooked or raw.

·         Eat eggs, including the yolk. Eggs contain lutein which is highly absorbed by the body. Having four per week is ideal.

·         Avoid high glycemic index and high glycemic load foods like refined grains and sugars. These foods are linked to diabetes and AMD.

This is a summary from studies and publications from Dr. Barbara Pelletier is an optomestrist and author of Eyefoods: A Food Plan for Healthy Eyes

 For chronic dry eyes, look to TheraLife for help.  TheraLife targets to restore and revive tear function to relief dry eye with your own tears.  No more drops, no oitment, Your own tears to relief dry eyes all day long.  All natural, 100% guaranteed.  

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New research Linking Sjogren's Disease to Hepatitis Delta Virus

Sjogrens Disease and Delta Hepatitis Virus

It has been long suspected that many autoimmune diseases are associated with a bout of viral infections.

New research from National Institute of Health indicate the virus Hepatitis delta Virus maybe associated with Primary Sjogren's Disease.   Of the 2 categories, Primary Sjogren's have more severe symptoms, and they do not have another rheumatic disease associated with it.

The salivary glands of Sjogren's patients were examined for viral vectors, changes in salivary flow, development of auto-antibodies compare to normal salivary glands.  This virus also demonstrated its ability to reduce saliva flow, increased lymphocyte infiltrates and development of auto-antibodies in mice.

Conclusion

Identification of HDV in Sjögren’s syndrome patients and induction of a Sjögren’s syndrome-like disease in vivo further support a viral-mediated etiopathology in Sjögren’s syndrome

This study was presented at

2015 ACR/ARHP Annual Meeting, September 29, 2015  atKeywords: Hepatitis, infection and viruses, SICCA, Sjogren's syndrome

Session Title: Infection-related Rheumatic Disease: Poster Session

How Can TheraLife Help?

TheralIfe Eye Autoimmune is a proprietary formula specifically designed to relief dry eye symptoms, control flares, and support healthy tear secretions from inside out. 

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We highly recommend hot compress for Sjogren's.  96% of Sjogren's people have meibomian gland dysfunction- clogged meibomian oil glands which produces lubricants to thicken tears. 

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The All Natural Treatment for Recurring Iritis- TheraLife Eye

Iritis is a common diagnosis that literally means "inflammation of the iris," the colored part of the eye. Anterior uveitis is a more technical term for iritis. There are many possible causes, and sometimes the cause cannot be identified. Due to the complexity of the vision system, any suspected case of eye inflammation should be examined by an optometrist, ophthalmologist or medical doctor. Most of the time, iritis resolves in less than 6 weeks; however, iritis can reoccur. It can signal  acute or chronic underlying disease in the body, and therefore should be cared for by a qualified healthcare professional. Without proper treatment, iritis can lead to cataracts, glaucoma, an irregularly sized and sluggish pupil, calcium deposits in the cornea, central serous choroidopathy, or retinal swelling (cystoid macular edema).

Leading Cause of Blindness

Iritis is the most common form of uveitis, a condition involving one or more of the three structures that comprise the intricate uvea. The iris is the front part of the uvea, the middle layer is the ciliary body (fine muscles that focus the eye) and at the back of the uvea is the choiroid which holds the small blood vessels 

How TheraLife Eye can Help!
Learn a new approach to treating recurring Iritis- by providing optimum natural anti-inflammatory functions without the damaging side effects of steroids and restore vascular health to eyes to prevent recurring Iritis. 

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How to manage and treat Ocular Rosacea

Ocular Rosacea

A diagnosis of ocular rosacea is most easily determined if the patient also presents with the dermatological signs associated with acne rosacea- spider veins on nose and cheeks, however, in 20% of  cases, ocular rosacea can occur without skin evidences. This makes the diagnosis more complicated. 

Ocular rosacea is highly probable in people who report persistent eye and lid redness, a gritty or foreign body sensation or frequent styes (chronic dry eyes). Slit lamp signs typically include thickened lid margins with telangiectasia, thick, turbid meibomian gland secretions and tear film debris- Meibomian Gland Dysfunction.  . Crusting and scales in the lashes are also quite common. In severe cases, individuals can develop corneal erosions, infiltrates and ulcers, and even suffer vision loss due to substantial scarring and neovascularization.

Early diagnosis and aggressive management is important for maintaining ocular health and preventing vision loss. Management can range from warm compresses, lid scrubs and lubrication in mild cases, to pulsed ophthalmic corticosteroids, topical azithromycin (off-label) and oral tetracyclines (i.e. doxycycline and minocycline) in moderate to severe cases. Tetracyclines are typically dosed well below therapeutic concentrations, since the goal is to utilize its anti-inflammatory properties and not necessarily its antibiotic traits. Long-term maintenance with topical ophthalmic cyclosporin has also shown to be effective and prescribing lid scrubs containing tea tree oil may also help, as there appears to be a link between ocular rosacea and a bacterium (Bacillus oleronius) commonly found on Demodex mites. Regardless of the treatment, patients must understand that rosacea is a chronic condition and long-term therapy is required to maintain control and slow progression.

Symptoms of Rosacea.  

Individuals with ocular rosacea may not realize that they have dermatological (skin) disease (or vice versa) because signs and symptoms can be subtle. If your have  experienced them for a long time, you may not even realize it’s abnormal. Family history of dermatological problems, or if they experience facial flushing, especially when embarrassed or after eating spicy foods, drinking alcohol or sun exposure. Look for redness, bumps or small blood vessels on the cheeks, nose and forehead. A diagnosis of rosacea is not to be taken lightly — more than 90% of sufferers report lowered self-esteem, and 2/5 of patients say the condition has caused them to avoid public contact.⁴ A referral to a dermatologist can be very helpful. 

This is an abstract from Dry Eye News, July 2015. 

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TheraLife® Eye works by restoring normal cell functions to both lacrimal and meibomian glands.  The result is balanced, sustainable tears from your own eye to provide comfort all day long.   Learn more
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1. National Rosacea Society. http://www.rosacea.org/class/classysystem.php (Accessed June 26, 2015)
2. Schechter BA, Katz RS, Friedman LS. Efficacy of topical cyclosporine for the treatment of ocular rosacea. Adv Ther. 2009 Jun;26(6):651-9
3. Li J, O'Reilly N, Sheha H, et al. Correlation between ocular Demodex infestation and serum immunoreactivity to Bacillus proteins in patients with facial rosacea. Ophthalmology. 2010;117:870-877.
4. National Rosacea Society. http://rosacea.org/rr/2013/fall/article_3.php (Accessed June 26, 2015) 

This is an abstract from 

Cataract Surgery and Dry Eye Syndrome

With cataracts affecting nearly 22 million Americans, it's not surprising that most of us know people who have had cataract surgery. We may even be contemplating cataract surgery for ourselves. Since cataracts are almost never a medical emergency, you should feel entirely comfortable taking the time to learn more about cataracts and explore all your options. 

What is a Cataract? 

A cataract is simply a spot on the lens of the eye that you cannot readily see through. These spots are made up of clumps of normal eye protein and generally form slowly over time. Although most cataracts are related to aging, it is also possible for cataracts to form as the result of surgery or other trauma to the eye. Steroid use and other health problems such as diabetes are also linked to cataracts. Congenital cataracts can form in babies or children, and radiation exposure can also result in cataracts. Still, for most people, cataracts are age-related and .

What is involved in Cataract surgery 

During cataract surgery, your own lens is removed and an artificial lens is replaced. The procedure is usually done under mild sedation and takes about an hour.  Most people see a remarkable improvement in their vision right after cataract surgery.  

Why do I have dry eyes after Cataract surgery?

In order to get the old lens out and the replacement lens in.  The doctor puts a tiny hole in your cornea to facilitate this process.  The hole does create an uneven surface on your cornea which creates friction when you blink.  This friction creates inflammation which shuts down your tear secretion glands, and thus dry eyes.

TheraLife Eye can help

Use TheraLife Eye for both pre-operative and post operative care.

The benefits of TheraLife Eye-

1. Effectively relief dry eyes without the use of eye drops and restore cornea to the best health it can be before surgery.
2. Post-operatively prevent dry eyes and maintain cornea health through accelerated healing, reduce inflammation, and continue secretion of balanced sustainable tear.
3. Avoid the use of steroids and side effects.

Testimonial from our customer

Cataract Induced Chronic Dry Eyes- Relief by TheraLife Eye
After cataract surgery in 2007.  I started having problems with dry eyes.  My doctor prescribed several different types of eye drops, but none were effective.  He then put plugs in my tear ducts, and they became infected and must be removed.  He then suggested that I have my tear ducts cauterized- I did not feel comfortable about this permanent procedure.
I then thought about going on the internet and checking what else is available for dry eyes.  Amazon had information on TheraLife Eye that I found the most interesting. I place an order.  Needless to say, I saw a marked improvement and now I am on a maintenance dose of one capsule at breakfast and one at dinner.  2 capsules per day.  I wouldn’t be without TheraLife Eye.
B.G,  Virginia Beach, VA
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New Research- Best Eye Warm Compress for Blepharitis /Meibomian Gland Dysfunction Treatment

Management of meibomian gland dysfunction (MGD) traditionally involves warm compresses as primary therapy. The exact temperature for a warm compress is unknown, but it has been advocated temperatures of between 40-45 degrees over 5-10 minutes are clinically effective. 

Conclusion- a hot wash cloth is just not good enough. 

The purpose of this study was to evaluate and compare the heat retention properties of commercially available eyelid warming masks over a 12-minute interval. Five eyelid-warming masks (MGDRxEyeBag, The Eye Doctor, Bruder eye hydrating compress, Tranquileyes and TheraPearl Eye-essential) and a warm facecloth were selected for this study to investigate their heat retention properties.

Not surprisingly, the facecloth is poor at maintaining the desired temperature for the prescribed 5-10 minutes without reheating. All the commercially available masks reached above 40°C within the first 2 minutes after heating and remained so for 5 minutes. The Bruder and Tranquileyes reached >50°C, after heating and the Bruder maintained >50°C for nearly 6 minutes. The MGDRx EyeBag and TheraPearl have the most stable heat retention (in targeted ranges) between 2 and 9 minutes.

Eye doctors prescribe warm compresses regularly for patients, and this study is an important reminder that facecloths are not a stable means of providing sustained heat to be clinically effective without reheating. The commercially available masks all provide sustained heat, though clinicians need to warn their patients that microwaves have different “strengths” and the patient needs to tailor their mask heating depending on the microwave wattage. 

This is an abstract from Ocular Surface News, April 9th, 2015. 

Blepharitis/Meibomian Gland Dysfunction result in inflammation which in turn shuts down your tear function.  

Relief Your Dry Eyes with TheraLife Eye

TheraLife Eye is a capsule.  It is not an eye drops.  TheraLife Eye revitalize your dry eyes intra-cellularly to secrete your own balanced tears.  Clinically proven to work in 80% first time users.  Get relief today.
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