The following is an abstract from the Clinical Immunology, Volume 145, Issue 3, December 2012, Pages 251–255
These new antibodies are:
1. SS- to salivary gland protein
2 CA6 - to caronic anhydrase 6
3. PSP- to paratoid secretory protein
The new antibodies were seen in 45 percent of patients who met most of the clinical criteria for Sjogren’s except for the antibodies currently required for diagnosis, called Ro and La.
At least one of the novel antibodies is present in 76 percent of patients who have had symptoms for less than two years and who also lacked the two antibodies required for definitive diagnosis, which appear late in the disease.
“The vast majority of patients we tested who have early symptoms of severe dry mouth and dry eyes also have these antibodies,”says Dr. Arbrus of University of Buffalo School of Medicine.
Sjogren’s Syndrome affects more than 4 million Americans, 90 percent of whom are women. Last year, tennis champion Venus Williams announced that she had the disease.
Symptoms are dry eyes and dry mouth so severe that they are painful. The disease is also associated with kidney and lung disease, lymphoma, cancer of the lymphocytes, a type of white blood cell that is continually produced in Sjogren’s Syndrome.
Once the new antibodies were detected in mice, the scientists started testing human patients at Buffalo General Medical Center. The researchers found the same antibodies in humans even at early stages of the disease.
University at Buffalo has filed a patent on the biomarker-based method and licensed the technology to Immco, which has developed a new diagnostic tool based on the research.
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